Spanish National Research Council · University of Seville
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Research Units » Design and Test of Mixed-Signal Integrated Circuits » Biomedical Circuits and Systems

Biomedical Circuits and Systems


Gloria Huertas Sánchez


Alberto Yúfera García


Keywords: biomedical circuits and systems; bio-sensors; laboratory on-a-chip (LoC); bioimpedance; microelectrode

(a) Cell growing and toxicity curves for several dosis obtained by our group. It is represented the resistance measure with commercial sensors versus time. (b) Commercial sensors. (c) Photograph of a cell culture over a 250 µm diameter microelectrode.
This research line embraces all activities related with the development of alternative bio-instrumentation circuits and systems required to reproduce classical and to propose new measurement techniques at bio-medical labs to improve the quality of acquired biosignals.
Targets design for bio-instrumentation systems are focused also to reduce the human effort and cost of biomedical assays, to obtain the minimum size and weight of biosystems (Lab-on-a-Chips, LoCs), to research new measurement methods based on high performance integrated circuits design with low-power consumption, wide bandwidth, reduced power supply levels and wireless communication capability. Electrical modeling of sensors required as signal transducers and interfaces must be incorporated to circuit design flow to obtain full system characterization. This research line also considers the modelling of heterogeneous systems for full system simulations.
Main recent activities are:
  • Alternative bio-signals acquisition techniques.
  • Development of CMOS circuits and systems blocks.
  • To exploit classical sensors and look for new sensor issues for solving biosignals and biomarkers measurement problem.
  • Modeling sensor performance and incorporate it into heterogeneous system simulation in a full system design process.
  • Developing multidisciplinary working skills.
Proposed circuit blocks for bio-impedance sensing: (a) Oscillation Based Test (OBT) proposed technique: impedance magnitude is obtained from oscilacion frequency parameters. (b) Closed-loop approach: magnitude and phase are obtained from signals Vm and VΦ respectively.
Research Highlights
D. Rivas-Marchena, A. Olmo, J.A. Miguel, M. Martinez, G. Huertas and A. Yufera, "Real-time electrical bioimpedance characterization of neointimal tissue for stent applications", Sensors, vol. 17, no. 8, art. 1737, 2017 » doi
G. Huertas, A. Maldonado, A. Yufera, A. Rueda and J.L. Huertas, "The Bio-Oscillator: A Circuit for Cell-Culture Assays", IEEE Transactions on Circuits and Systems II: Express Briefs, vol. 62, pp. 164-168, 2015 » doi
P. Pérez, A. Maldonado-Jacobi, A.J. López, C. Martínez, A. Olmo, G. Huertas and A. Yufera, "Remote Sensing of Cell Culture Assays". in Sivakumar Joghi Thatha Gowder (Ed.), New Insights into Cell Culture Technology, InTech Europe, 2017 » doi
Technology Transfer
Gloria Huertas Sánchez, Andrés Maldonado Jacobi and Alberto Yúfera García. Bioimpedance measurement system for wirelessly monitoring cell cultures in real time, based on an oscillation test using integrated circuits. 2014 » pdf
Alberto Yúfera García, Alberto Olmo Fernández and Gloria Huertas Sánchez. Bioimpedance measuring system for wirelessly monitoring cell cultures in real time, based on CMOS circuits and electrical modelling. 2014 » pdf
Key Research Projects & Contracts
MIXCELL: Integrated MicroSystems for Cell-Culture Assays
PI: Alberto Yúfera García
Funding Body: Min. de Economía y Competitividad
Jan 2014 - Dec 2017
DANTE: Adapting Mixed-signal and RF ICs Design and Test to Process and Evironment Variability (TEC2011-28302)
PI: Adoración Rueda Rueda
Funding Body: Min. de Ciencia e Innovación
Jan 2012 - Dec 2014
ACATEX: Self-calibration and self-test of analog, mixed-signal and radio frecuency circuits (P09-TIC-5386)
PI: Adoración Rueda Rueda
Funding Body: Junta de Andalucía - Proyectos de Excelencia
Mar 2010 - Feb 2014
Sistema integrado para la monitorización y caracterización de cultivos celulares en tiempo real
PI: Alberto Yúfera García
Funding Body: Universidad de Sevilla